Kermet Apio was born and raised in Honolulu, Hawaii. He often mocks his name, often comparing it to a certain Muppet character in his comedy. After graduating high school, Apio moved to Seattle, Washington, which would later become his home. Apio later became involved in stand-up comedy, where he gained worldwide recognition after winning the Great American Comedy Festival, where he suddenly became swamped with gigs and requests, where Apio used his travel experiences in his comedy. He has appeared at The Improv, The Comedy Cave, The Orpheum of Sioux Falls, the ACME comedy Company in Minneapolis, and comedy festivals all over the world, including China, Israel, New Zealand, and Canada. He has also appeared on channels such as A&E, and PBS. Apio has released his own CD, titled Unarmed and Lethargic.